Abstract | BACKGROUND: METHOD: The patient received either placebo or drug in a double-blinded fashion in increasing doses in each of three 2-week phases (A = placebo, B = methylphenidate, C = placebo). Blinded outcomes of depression and cognition were measured initially and twice in each phase. Depression was measured using the Hamilton Rating Scale for Depression (HAM-D) and a mood self-assessment scale. Cognition was measured using the digit span (forward and backward subtest of the Wechsler Adult Intelligence Scale-Revised, Trail-Making Tests A and B, and the Symbol Digit Modalities Test (SDMT). RESULTS: HAM-D scores improved during the methylphenidate phase (initial = 33; A = 23, 25; B = 15, 10; C = 28, 27), as did the subjective mood assessment ratings. Digit span backward scores improved with the drug (initial = 4; A = 4, 3; B = 6, 8; C = 5, 4), as did Trail-Making Test B scores (initial = 125 seconds; A = 133, 103 seconds; B = 86, 82 seconds; C = 88, 96 seconds). Digit span forward, SDMT, and Trail-Making Test A, however, showed no drug-related trend. CONCLUSION: We conclude that methylphenidate was beneficial in the treatment of depression in this patient with AIDS.
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Authors | J C White, J F Christensen, C M Singer |
Journal | The Journal of clinical psychiatry
(J Clin Psychiatry)
Vol. 53
Issue 5
Pg. 153-6
(May 1992)
ISSN: 0160-6689 [Print] United States |
PMID | 1592840
(Publication Type: Case Reports, Clinical Trial, Controlled Clinical Trial, Journal Article)
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Chemical References |
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Topics |
- AIDS Dementia Complex
(diagnosis, drug therapy, psychology)
- Ambulatory Care
- Cognition
(drug effects)
- Depressive Disorder
(diagnosis, drug therapy, psychology)
- Double-Blind Method
- Humans
- Male
- Methylphenidate
(therapeutic use)
- Middle Aged
- Personality Inventory
- Placebos
- Psychiatric Status Rating Scales
- Psychological Tests
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