Evaluation of left ventricular function in long-term survivors of childhood Hodgkin disease.

Abstract

BACKGROUND:

Data on the presence of myocardial abnormalities in long-term Hodgkin disease survivors are contradictory. The purpose of this study was to determine if myocardial performance index (MPI) was capable of discovering cardiac abnormalities.

PROCEDURE:

Echocardiographic evaluation was performed in 31 survivors of Hodgkin disease (mean age 17.0 years), who received doxorubicin as part of chemotherapeutic treatment (median dose 164.8 +/- 42.5 mg/m(2)). Control group comprised 22 healthy subjects (mean age 16.7 years).

RESULTS:

Peak A velocity was increased (P = 0.004) and peak E/A velocity ratio was lower (P = 0.002) in patients compared to controls. Mean isovolumetric contraction time was longer in patients than in controls (P = 0.0001). Ejection time was significantly shorter in patients than in the controls (P = 0.001). Consequently, the MPI was significantly greater in the patients than in the controls (P = 0.0001). Abnormal MPI was found in 25/31 patients (83%).

CONCLUSIONS:

The Doppler-derived index of combined systolic and diastolic myocardial performance demonstrates the presence of subtle cardiac abnormalities in the majority of Hodgkin disease survivors.

• Authors: Diana Iarussi, Carlo Pisacane, Paolo Indolfi, Fiorina Casale, Vincenzo Martino, Maria Teresa Di Tullio
• Journal: Pediatric blood & cancer (Pediatr Blood Cancer) Vol. 45 Issue 5 Pg. 700-5 (Oct 15 2005) ISSN: 1545-5009 [Print] United States
• PMID: 15926158 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Adolescent
• Echocardiography
• Female
• Hemodynamics
• Hodgkin Disease (complications, physiopathology)
• Humans
• Male
• Survivors
• Ventricular Dysfunction, Left (diagnostic imaging, etiology)
• Ventricular Function, Left