Nephronophthisis.

Abstract

There has been tremendous progress in the past few years in understanding the molecular basis of nephronophthisis, and it is now evident that the disease is characterized by both clinical and genetic heterogeneity. Within the three different clinical forms there is a large spectrum of phenotypes, which have been associated, to date, with five gene defects. These genes encode proteins that localize in different cell compartments - in particular, to the primary apical cilia - as is the case for virtually all gene products involved in cystic kidney diseases. Two animal models with mutations in the mouse orthologs of the genes involved in the adolescent and infantile forms also exist. These models have been of considerable help in deciphering disease pathogenesis.

• Authors: Sophie Saunier, Rémi Salomon, Corinne Antignac
• Journal: Current opinion in genetics & development (Curr Opin Genet Dev) Vol. 15 Issue 3 Pg. 324-31 (Jun 2005) ISSN: 0959-437X [Print] England
• PMID: 15917209 (Publication Type: Journal Article, Review)

Topics

• Animals
• Humans
• Kidney Diseases (genetics, metabolism, pathology)
• Mutation (genetics)
• Syndrome