Abstract | BACKGROUND: METHODS: RESULTS: During 14 years of follow-up, we documented 2356 new cases of symptomatic gallstones. After adjusting for age and other potential risk factors, we found that compared with men in the lowest quintile of dietary intake of trans-fatty acids, the relative risk (RR) of gallstone disease for those in the highest quintile was 1.23 (95% confidence interval [CI], 1.04-1.44; P for trend, .03). Among individual trans-fatty acids, the RR for trans-oleic fatty acid, when extreme quintiles were compared, was 1.24 (95% CI, 1.06-1.45; P for trend, .02). Intakes of trans-palmitoleic fatty acid (RR, 1.09; 95% CI, 0.90-1.31), trans,trans 18:2 fatty acid (RR, 1.14; 95% CI, 0.96-1.34), and cis-trans 18:2 fatty acid (RR, 1.00; 95% CI, 0.86-1.16) were not significantly associated with the risk. CONCLUSIONS:
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Authors | Chung-Jyi Tsai, Michael F Leitzmann, Walter C Willett, Edward L Giovannucci |
Journal | Archives of internal medicine
(Arch Intern Med)
Vol. 165
Issue 9
Pg. 1011-5
(May 09 2005)
ISSN: 0003-9926 [Print] United States |
PMID | 15883239
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
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Topics |
- Adult
- Aged
- Diet
- Diet Surveys
- Follow-Up Studies
- Gallstones
(chemically induced, epidemiology)
- Health Personnel
- Humans
- Incidence
- Life Style
- Male
- Middle Aged
- Prospective Studies
- Trans Fatty Acids
(administration & dosage, adverse effects)
- United States
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