Autoimmune
neurological disorders are very common. Health-related quality-of-life measures, obtained through a patient-oriented tool (a self-administered questionnaire), are now considered essential in the evaluation of
therapies, especially for pathologies that may affect patients' general status. We reviewed the most common autoimmune
neurological disorders and their treatment, and we report on our experience on
intravenous immunoglobulin (
IVIG) administration and the relationship between
IVIG and health-related quality of life. Generally,
IVIG administration is effective in the most common autoimmune neurological diseases. Concerning the relationship between
IVIG treatment and health-related quality of life, our results reveal an improvement of physical aspects of patients' health-related quality of life after
IVIG administration. Conversely, the comparison of mental scores between the evaluation at baseline and the evaluation at follow-up exhibited no difference. Although the use of
IVIG is effective for autoimmune
neurological disorders, there are no commonly accepted protocols for the use of
IVIG treatment. Further controlled studies on
IVIG, including quality-of-life assessments, are necessary to develop needed evidence on the use of
IVIG in clinical practice.