Constituents of the leaves and twigs of Calyptranthes pallens collected from an experimental plot in Southern Florida.

Abstract

Fractionation of the chloroform-soluble extract of the leaves and twigs of Calyptranthes pallens, collected from an experimental plot in a hardwood forest of southern Florida, using a hormone-dependent human prostate carcinoma (LNCaP) tumor cell line, led to the isolation of a phloroglucinol derivative with a novel carbon skeleton, pallenic acid (1), and a new triterpenoid, 3beta-hydroxy-18alpha,19alpha-urs-20-en-28-oic acid (2). The known compound methylene-bis-aspidinol (3) was selectively active against the human oral epidermoid carcinoma (KB) cell line. Several known compounds of the ellagic acid, lignan, phloroglucinol, sterol, and triterpene types were also obtained in the present investigation.

• Authors: Tatiana Lobo-Echeverri, J Fausto Rivero-Cruz, Bao-Ning Su, Hee-Byung Chai, Geoffrey A Cordell, John M Pezzuto, Steven M Swanson, D Doel Soejarto, A Douglas Kinghorn
• Journal: Journal of natural products (J Nat Prod) Vol. 68 Issue 4 Pg. 577-80 (Apr 2005) ISSN: 0163-3864 [Print] United States
• PMID: 15844953 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• 3beta-hydroxy-18alpha,19alpha-urs-20-en-28-oic acid
• Antineoplastic Agents, Phytogenic
• Heterocyclic Compounds, 3-Ring
• Triterpenes
• pallenic acid

Topics

• Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, pharmacology)
• Drug Screening Assays, Antitumor
• Florida
• Heterocyclic Compounds, 3-Ring (chemistry, isolation & purification, pharmacology)
• Humans
• KB Cells
• Molecular Structure
• Myrtaceae (chemistry)
• Nuclear Magnetic Resonance, Biomolecular
• Plant Leaves (chemistry)
• Plants, Medicinal (chemistry)
• Triterpenes (chemistry, isolation & purification, pharmacology)
• Tumor Cells, Cultured