[Current diagnosis and therapy of malignant hyperthermia].

Abstract

Malignant hyperthermia is an autosomal dominant disorder which results in a severe reaction to anesthetic agents in approximately 0.0005 to 0.5% of patients exposed to general anesthesia. Malignant hyperthermia is characterized by severe muscle rigidity, myoglobunuria, high fever, tachycardia, and arrhythmia precipitated by depolarizing muscle relaxants (succinylcholine) and inhalational anesthetic agents (halothane). When MH occurs, the anesthetic agents must be discontinued immediately and dantrolene should be administered.

• Authors: T Kobayashi
• Journal: Clinical calcium (Clin Calcium) Vol. 11 Issue 11 Pg. 1475-80 (Nov 2001) ISSN: 0917-5857 [Print] Japan
• PMID: 15775667 (Publication Type: English Abstract, Journal Article)