Mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADalpha, and MO25alpha, in Peutz-Jeghers syndrome.

Abstract

Mutations in LKB1 lead to Peutz-Jeghers syndrome (PJS). However, only a subset of PJS patients harbours LKB1 mutations. We performed a mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADalpha, and MO25alpha, in 28 LKB1-negative PJS patients. No disease-causing mutations were detected in the studied genes in PJS patients from different European populations.

• Authors: P Alhopuro, P Katajisto, R Lehtonen, S K Ylisaukko-Oja, L Näätsaari, A Karhu, A M Westerman, J H P Wilson, F W M de Rooij, T Vogel, G Moeslein, I P Tomlinson, L A Aaltonen, T P Mäkelä, V Launonen
• Journal: British journal of cancer (Br J Cancer) Vol. 92 Issue 6 Pg. 1126-9 (Mar 28 2005) ISSN: 0007-0920 [Print] England
• PMID: 15756273 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adaptor Proteins, Signal Transducing
• Adaptor Proteins, Vesicular Transport
• Nuclear Proteins
• STRADA protein, human
• Transcription Factors
• SMARCA4 protein, human
• DNA Helicases

Topics

• Adaptor Proteins, Signal Transducing (genetics)
• Adaptor Proteins, Vesicular Transport (genetics)
• DNA Helicases
• Humans
• Introns
• Mutation
• Nuclear Proteins (genetics)
• Peutz-Jeghers Syndrome (genetics)
• Polymorphism, Genetic
• Transcription Factors (genetics)