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Galanin-like peptide stimulates vasopressin, oxytocin and adrenocorticotropic hormone release in rats.

Abstract
Galanin-like peptide is a recently identified neuropeptide. We examined the effects of stressful stimuli on expression of c-Fos protein in galanin-like peptide neurons, and the effects of central infusion of galanin-like peptide on release of stress hormones, vasopressin, oxytocin and adrenocorticotropic hormone, in male rats. Foot shock stress induced expression of c-Fos protein in galanin-like peptide neurons in the hypothalamus. Intracerebroventricular injection of galanin-like peptide significantly increased plasma concentrations of vasopressin, oxytocin and adrenocorticotropic hormone. Galanin-like peptide also increased blood pressure, heart rates and plasma glucose concentrations, but significantly changed neither plasma osmolality nor blood haemoglobin concentration. A neuropeptide Y-Y1 receptor antagonist, BIBP3226, did not significantly change galanin-like peptide-induced hormone release. It is possible that galanin-like peptide is involved in vasopressin, oxytocin and adrenocorticotropic hormone release from the pituitary during stress.
AuthorsTatsushi Onaka, Motoki Kuramochi, Jun Saito, Yoichi Ueta, Toshihiko Yada
JournalNeuroreport (Neuroreport) Vol. 16 Issue 3 Pg. 243-7 (Feb 28 2005) ISSN: 0959-4965 [Print] England
PMID15706228 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Blood Glucose
  • Galanin-Like Peptide
  • Proto-Oncogene Proteins c-fos
  • Receptors, Neuropeptide Y
  • Vasopressins
  • Oxytocin
  • Adrenocorticotropic Hormone
Topics
  • Adrenocorticotropic Hormone (blood)
  • Animals
  • Blood Glucose (drug effects)
  • Cell Count (methods)
  • Dose-Response Relationship, Drug
  • Drug Interactions
  • Electroshock (methods)
  • Galanin-Like Peptide (metabolism, pharmacology)
  • Hypothalamus (cytology)
  • Immunohistochemistry (methods)
  • Injections, Intraventricular (methods)
  • Male
  • Neurons (drug effects, metabolism)
  • Osmolar Concentration
  • Oxytocin (blood)
  • Proto-Oncogene Proteins c-fos (metabolism)
  • Rats
  • Rats, Wistar
  • Receptors, Neuropeptide Y (antagonists & inhibitors)
  • Time Factors
  • Vasopressins (blood)

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