Abstract |
Galanin-like peptide is a recently identified neuropeptide. We examined the effects of stressful stimuli on expression of c-Fos protein in galanin-like peptide neurons, and the effects of central infusion of galanin-like peptide on release of stress hormones, vasopressin, oxytocin and adrenocorticotropic hormone, in male rats. Foot shock stress induced expression of c-Fos protein in galanin-like peptide neurons in the hypothalamus. Intracerebroventricular injection of galanin-like peptide significantly increased plasma concentrations of vasopressin, oxytocin and adrenocorticotropic hormone. Galanin-like peptide also increased blood pressure, heart rates and plasma glucose concentrations, but significantly changed neither plasma osmolality nor blood haemoglobin concentration. A neuropeptide Y-Y1 receptor antagonist, BIBP3226, did not significantly change galanin-like peptide-induced hormone release. It is possible that galanin-like peptide is involved in vasopressin, oxytocin and adrenocorticotropic hormone release from the pituitary during stress.
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Authors | Tatsushi Onaka, Motoki Kuramochi, Jun Saito, Yoichi Ueta, Toshihiko Yada |
Journal | Neuroreport
(Neuroreport)
Vol. 16
Issue 3
Pg. 243-7
(Feb 28 2005)
ISSN: 0959-4965 [Print] England |
PMID | 15706228
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Glucose
- Galanin-Like Peptide
- Proto-Oncogene Proteins c-fos
- Receptors, Neuropeptide Y
- Vasopressins
- Oxytocin
- Adrenocorticotropic Hormone
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Topics |
- Adrenocorticotropic Hormone
(blood)
- Animals
- Blood Glucose
(drug effects)
- Cell Count
(methods)
- Dose-Response Relationship, Drug
- Drug Interactions
- Electroshock
(methods)
- Galanin-Like Peptide
(metabolism, pharmacology)
- Hypothalamus
(cytology)
- Immunohistochemistry
(methods)
- Injections, Intraventricular
(methods)
- Male
- Neurons
(drug effects, metabolism)
- Osmolar Concentration
- Oxytocin
(blood)
- Proto-Oncogene Proteins c-fos
(metabolism)
- Rats
- Rats, Wistar
- Receptors, Neuropeptide Y
(antagonists & inhibitors)
- Time Factors
- Vasopressins
(blood)
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