[Allogeneic bone marrow transplantation for a patient with malignant histiocytosis].

Abstract

OBJECTIVE:

To observe the efficacy and side effects of allogeneic bone marrow transplantation (allo-BMT) in the treatment of malignant histiocytosis (MH).

METHODS:

After conditioning with chemotherapy and total body irradiation, HLA-A, B, DR, DQ compatible allo-BMT was performed in a patient with MH.

RESULTS:

DNA fingerprinting showed engraftment on day 22, bone marrow aspiration showed hypercellularity on day 50, and no abnormal cell was found. The patient developed acute graft-versus-host disease ( II degrees) on day 40 and herpes zoster 6 months post-transplantation, and the patient has survived disease-freely for 24 months after allo-BMT.

CONCLUSION:

This is the first report of treatment of MH with allo-BMT in China, showing that allo-BMT may significantly prolong the survival of MH.

• Authors: M Zhai, L Hu, H Chen
• Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi (Zhonghua Xue Ye Xue Za Zhi) Vol. 18 Issue 8 Pg. 395-6 (Aug 1997) ISSN: 0253-2727 [Print] China
• PMID: 15625841 (Publication Type: Case Reports, English Abstract, Journal Article)

Topics

• Adult
• Bone Marrow Transplantation
• Female
• Follow-Up Studies
• Histiocytic Sarcoma (blood, pathology, physiopathology, surgery)
• Humans
• Leukocyte Count
• Middle Aged
• Survival Analysis
• Transplantation, Homologous