Gene expression profile of an adenomyoepithelioma of the breast with a reciprocal translocation involving chromosomes 8 and 16.

Abstract

Myoepithelium is an integral part of the mammary ductal and lobular architecture, positioned between luminal cells and the basement membrane. We describe the first report on cytogenetic findings in an adenomyoepithelioma of the breast with a balanced t(8;16)(p23;q21), and provide gene expression profile using Affymetrix GeneChip U95AV2 (Affymetrix, Santa Clara, CA). Differential analysis identified 857 genes with 2-fold or more mRNA change in comparison to pooled normal breast control; immunohistochemical analysis was used to confirm these results in a limited number of genes. Expression results were grouped based on the chromosomal location of the genes and associated protein function, and identified several potential pathogenetic mechanisms (autocrine and paracrine growth stimuli) in the development of myoepithelial tumors.

• Authors: Zoran Gatalica, Gopalrao Velagaleti, Helena Kuivaniemi, Gerard Tromp, Juan Palazzo, Kerry M Graves, Michelle Guigneaux, Thomas Wood, Mala Sinha, Bruce Luxon
• Journal: Cancer genetics and cytogenetics (Cancer Genet Cytogenet) Vol. 156 Issue 1 Pg. 14-22 (Jan 01 2005) ISSN: 0165-4608 [Print] United States
• PMID: 15588851 (Publication Type: Journal Article)

Topics

• Aged
• Breast Neoplasms (genetics)
• Chromosomes, Human, Pair 16
• Chromosomes, Human, Pair 8
• Female
• Gene Expression Profiling
• Humans
• Immunohistochemistry
• Myoepithelioma (genetics)
• Translocation, Genetic