Cervical artery dissection: An atypical presentation with Ehlers-Danlos-like collagen pathology?

Abstract

The authors took skin biopsies of the macroscopically normal skin of seven consecutive patients with spontaneous cervical artery dissection (SCAD). Histologically, alterations of the collagen and elastic fiber networks were found in six patients. In five, the histologic, immunohistochemical, and ultrastructural changes were similar to those usually found in Ehlers-Danlos syndrome (EDS). This suggests that SCAD is frequently associated with the dermal alterations seen in EDS.

• Authors: D Ulbricht, N J Diederich, T Hermanns-Lê, R J Metz, F Macian, G E Piérard
• Journal: Neurology (Neurology) Vol. 63 Issue 9 Pg. 1708-10 (Nov 09 2004) ISSN: 1526-632X [Electronic] United States
• PMID: 15534262 (Publication Type: Journal Article)

Chemical References

• Fibrillar Collagens

Topics

• Adult
• Biopsy
• Carotid Artery, Internal, Dissection (diagnosis, pathology)
• Ehlers-Danlos Syndrome (pathology)
• Elastic Tissue (pathology, ultrastructure)
• Female
• Fibrillar Collagens (ultrastructure)
• Humans
• Male
• Middle Aged
• Skin (pathology, ultrastructure)
• Vertebral Artery Dissection (diagnosis, pathology)