Anti-G protein antibody responses to respiratory syncytial virus infection or vaccination are associated with inhibition of G protein CX3C-CX3CR1 binding and leukocyte chemotaxis.

Abstract	Respiratory syncytial virus (RSV) is an important cause of severe lower respiratory tract illness in infants and the elderly. Presently, no safe and efficacious RSV vaccine exists; however, advances in our understanding of immunity and the pathogenesis of disease associated with RSV infection may lead to new vaccine strategies. RSV G protein contains a CX3C chemokine motif that interacts with the CX3CR1 chemokine receptor and modifies the activities of fractalkine. In the present study, we show that anti-RSV G protein antibody responses after recent RSV infection or vaccination are associated with inhibition of RSV G protein CX3C-CX3CR1 interaction and RSV G protein-mediated leukocyte chemotaxis.
Authors	Jennifer L Harcourt, Ruth A Karron, Ralph A Tripp
Journal	The Journal of infectious diseases (J Infect Dis) Vol. 190 Issue 11 Pg. 1936-40 (Dec 01 2004) ISSN: 0022-1899 [Print] United States
PMID	15529257 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References	Antibodies, Viral CX3C Chemokine Receptor 1 CX3CL1 protein, human CX3CR1 protein, human Chemokine CX3CL1 Chemokines, CX3C Membrane Proteins Receptors, Chemokine Respiratory Syncytial Virus Vaccines Vaccines, Attenuated Viral Proteins
Topics	Adult Antibodies, Viral (analysis, biosynthesis) Binding Sites, Antibody CX3C Chemokine Receptor 1 Chemokine CX3CL1 Chemokines, CX3C (chemistry, immunology) Chemotaxis, Leukocyte Child, Preschool Humans Infant Leukocytes (immunology) Membrane Proteins (immunology) Receptors, Chemokine (immunology) Respiratory Syncytial Virus Infections (immunology, prevention & control, virology) Respiratory Syncytial Virus Vaccines (administration & dosage, immunology) Respiratory Syncytial Virus, Human (immunology) Vaccination Vaccines, Attenuated (administration & dosage, immunology) Viral Proteins (antagonists & inhibitors, chemistry, immunology)

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