Antiplaque and antigingivitis efficacy of toothpastes containing Triclosan and fluoride.

Abstract

OBJECTIVE:

To compare the reduction of plaque and gingivitis from the following three toothpaste formulations containing: 0.3% Triclosan, 1,000ppm fluoride and 0.13% calcium glycerophosphate in a natural calcium carbonate base (a new paste); 0.2% Triclosan and 1,000ppm fluoride in a precipitated calcium carbonate base; 0.3% Triclosan, 1,000ppm fluoride and Gantrez in a silica base. A control group was maintained, which used commercially available toothpastes without the above actives.

METHODS:

A double-blind, four-cell, stratified, parallel group design study. Subjects brushed twice daily with their allocated toothpaste for 12 weeks. Plaque, MGI and gingival bleeding assessments were carried out at baseline, after 6 and 12 weeks of product use.

RESULTS AND CONCLUSION:

An analysis of covariance of the 12-week results showed significant differences between products [p<0.0001] for plaque, MGI and gingival bleeding. The new toothpaste formulation containing 0.3% Triclosan, 1,000ppm fluoride and 0.13% calcium glycerophosphate in a natural calcium carbonate base was shown to be significantly more effective in reducing plaque and gingivitis than the other toothpaste formulations in the study.

• Authors: S Peter, D G Nayak, P Philip, N S Bijlani
• Journal: International dental journal (Int Dent J) Vol. 54 Issue 5 Suppl 1 Pg. 299-303 ( 2004) ISSN: 0020-6539 [Print] England
• PMID: 15509080 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)

Chemical References

• Anti-Infective Agents, Local
• Cariostatic Agents
• Glycerophosphates
• Toothpastes
• Triclosan
• Silicon Dioxide
• Calcium Carbonate
• Fluorides

Topics

• Adolescent
• Adult
• Anti-Infective Agents, Local (administration & dosage, therapeutic use)
• Calcium Carbonate (administration & dosage)
• Cariostatic Agents (administration & dosage, therapeutic use)
• Dental Plaque (prevention & control)
• Dental Plaque Index
• Double-Blind Method
• Fluorides (administration & dosage, therapeutic use)
• Follow-Up Studies
• Gingival Hemorrhage (prevention & control)
• Gingivitis (prevention & control)
• Glycerophosphates (administration & dosage)
• Humans
• Middle Aged
• Periodontal Index
• Silicon Dioxide (administration & dosage)
• Toothbrushing
• Toothpastes (therapeutic use)
• Treatment Outcome
• Triclosan (administration & dosage, therapeutic use)