Abstract |
Recently, intravenous therapy with pamidronate has been reported to be effective for treating fibrous dysplasia. However, very little is known about the efficacy of oral alendronate for fibrous dysplasia. We describe a patient with polyostotic fibrous dysplasia, who had complained of persistent pain for more than 20 years, that was treated with oral alendronate alone. Follow-up examinations were at intervals of 3 months for 2 years. The pain, radiographic findings, and bone turnover, which was monitored using various markers, improved. No adverse side effect was noted. Oral alendronate is suggested to be a useful option in the treatment of polyostotic fibrous dysplasia.
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Authors | Yasuyuki Kitagawa, Kensuke Tamai, Hiromoto Ito |
Journal | Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association
(J Orthop Sci)
Vol. 9
Issue 5
Pg. 521-5
( 2004)
ISSN: 0949-2658 [Print] Japan |
PMID | 15449129
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Administration, Oral
- Alendronate
(administration & dosage, therapeutic use)
- Bone Regeneration
(drug effects)
- Female
- Fibrous Dysplasia, Polyostotic
(diagnostic imaging, drug therapy)
- Humans
- Middle Aged
- Radiography
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