Cisplatin and 5-fluorouracil in advanced cancer of the penis.

Abstract

A total of 8 patients with advanced squamous cell carcinoma of the penis (Jackson stages III and IV) received chemotherapy with 100 mg./m2. cisplatin intravenously on day 1 and a 24-hour infusion of 1,000 mg./m.2 5-fluorouracil on days 1 to 5. Of the patients 2 (25%) achieved a partial response: 1 required a further operation and 1 required surgery with radiotherapy to achieve a complete response. These 2 patients were disease-free at 32+ and 57+ months. Nonresponders had a survival range of 2+ to 28 months after chemotherapy. Nausea and vomiting were the most frequent side effects of chemotherapy. Chemotherapy-related increase in serum creatinine occurred in 3 patients. Two patients had septicemia and 1 complained of tinnitus. Poor tolerability especially in the elderly was the main reason for discontinuing chemotherapy. The combination of cisplatin and 5-fluorouracil may have a role in the management of advanced penile cancer together with surgery and radiotherapy.

• Authors: F V Shammas, S Ous, S D Fossa
• Journal: The Journal of urology (J Urol) Vol. 147 Issue 3 Pg. 630-2 (Mar 1992) ISSN: 0022-5347 [Print] United States
• PMID: 1538445 (Publication Type: Journal Article)

Chemical References

• Cisplatin
• Fluorouracil

Topics

• Adult
• Aged
• Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
• Carcinoma, Squamous Cell (drug therapy, secondary)
• Cisplatin (administration & dosage)
• Fluorouracil (administration & dosage)
• Humans
• Male
• Middle Aged
• Penile Neoplasms (drug therapy, pathology)