Abstract | BACKGROUND: The risk of developing the human papillomavirus (HPV)-associated precancer high-grade squamous intraepithelial lesion (HSIL) in human immunodeficiency virus (HIV)-infected adolescents is unknown. We examined the risk of developing HSIL among adolescents with and without HIV infection. METHODS: HIV-infected (n = 172) and -uninfected (n = 84) girls aged 13-18 years who were participating in a multicenter study of primarily horizontally acquired HIV infections in adolescents (Reaching for Excellence in Adolescent Health Care) and who did not have HSIL on cytologic examination at study entry or at the first follow-up visit were followed at 6-month intervals. HIV-uninfected girls were recruited for comparison in a 2:1 ratio (HIV infected:HIV uninfected). The primary outcome was cytologic diagnosis of HSIL confirmed by expert review. RESULTS: CONCLUSIONS: The incidence of HSIL was alarmingly high in HIV-infected adolescent girls. However, when other predictors were considered in multivariate analysis, HIV status was not retained in the model. The heightened risk for HSIL associated with persistent LSIL underscores the need to closely monitor HIV-infected adolescents with LSIL. The risk for HSIL associated with high concentrations of IL-12 may be suggestive of a local immune dysregulation. The role of hormonal contraception as a risk factor deserves further investigation.
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Authors | Anna-Barbara Moscicki, Jonas H Ellenberg, Peggy Crowley-Nowick, Teresa M Darragh, Jiahong Xu, Sepidah Fahrat |
Journal | The Journal of infectious diseases
(J Infect Dis)
Vol. 190
Issue 8
Pg. 1413-21
(Oct 15 2004)
ISSN: 0022-1899 [Print] United States |
PMID | 15378433
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Research Support, U.S. Gov't, P.H.S.)
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Copyright | Copyright 2004 Infectious Diseases Society of America |
Chemical References |
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Topics |
- Adolescent
- Confidence Intervals
- Female
- HIV Infections
(blood, complications, epidemiology)
- Humans
- Incidence
- Interleukin-12
(blood)
- Multivariate Analysis
- Neoplasms, Squamous Cell
(epidemiology, etiology)
- Papillomavirus Infections
(blood, epidemiology, etiology)
- Precancerous Conditions
(epidemiology, etiology)
- Prospective Studies
- Risk Factors
- Sexual Behavior
- United States
(epidemiology)
- Uterine Cervical Dysplasia
(epidemiology, etiology)
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