N-(1-Deoxy-D-fructos-1-yl)-l-amino
acids isolated from hog liver are endogenous lead decorporation substances with low toxicity and cell membrane crossing ability. To simulate the effect of the natural N-(1-deoxy-D-fructos-1-yl)-l-amino
acids on lead decorporation, a series of the epimerically pure N-(1-deoxy-D-fructos-1-yl)-l-amino
acids (6a-e beta) were synthesized, and their usefulness as antagonists of lead intoxication was investigated. The results suggest that
after treatment with 6a-e beta the liver, kidney, bone, and brain, lead levels of mice were significantly reduced in comparison with the control group. Except for bone and brain lead levels of the mice after chelating treatment with 6d beta, all of the other tissue lead levels of mice after chelating treatment with 6a-e beta are significantly lower than those of mice
after treatment with dl-
penicillamine (p < 0.05). All fecal lead levels of mice
after treatment with 6a-e beta are significantly higher than those of mice
after treatment with
0.9% saline (controls) and dl-
penicillamine (p < 0.05-0.01). The effects of all
chelating agents on urinary excretion of lead in mice are clearly superior to the control (p < 0.05-0.01). The results of the present studies on repeated lead exposure indicated that at tested levels of i.p.
injections, the
fructose-
amino acids were effective antagonists of
lead poisoning under the experimental conditions.
After treatment with the
chelators, the concentration of essential metals in mice did not exhibit change as compared to the control. The effects of the compounds on
cadmium decorporation were also investigated, and similar results were observed.