Application of the poly-N-acetyl glucosamine-derived rapid deployment hemostat trauma dressing in severe/lethal Swine hemorrhage trauma models.

Abstract

BACKGROUND:

The Rapid Deployment Hemostat (RDH) Bandage was developed for the rapid control of bleeding caused by trauma.

METHODS:

An extremity wound involving skin, muscle, bone, and femoral arterial injury and a 1-cm vertical incision in the abdominal aorta in swine were studied to compare the RDH Bandage, a fibrin sealant dressing and gauze to restore hemostasis. The total blood loss was determined and the survival of animals was measured.

RESULTS:

In the extremity injury model, the RDH Bandage reduced blood loss by 63% compared with the gauze control. In the aorta arterial incision model, the RDH Bandage required a significantly lower compression time to control bleeding compared with gauze and TachoComb. The RDH Bandage was able to stop bleeding from this injury in 100% of the tests.

CONCLUSION:

The RDH Bandage was superior to a commercially available fibrin bandage in controlling hemorrhage, decreasing blood loss, and increasing survival.

• Authors: Raymond J Connolly
• Journal: The Journal of trauma (J Trauma) Vol. 57 Issue 1 Suppl Pg. S26-8 (Jul 2004) ISSN: 0022-5282 [Print] United States
• PMID: 15280747 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Drug Combinations
• Hemostatics
• poly-N-acetyl glucosamine
• tachocomb
• Fibrinogen
• Aprotinin
• Thrombin
• Acetylglucosamine

Topics

• Acetylglucosamine (chemistry, pharmacology, therapeutic use)
• Animals
• Aorta, Abdominal (injuries)
• Aprotinin (therapeutic use)
• Bandages (standards)
• Blood Cell Count
• Blood Volume
• Chemistry, Pharmaceutical
• Disease Models, Animal
• Drug Combinations
• Drug Evaluation, Preclinical
• Femoral Artery (injuries)
• Fibrinogen (therapeutic use)
• Hemorrhage (diagnosis, drug therapy, etiology, mortality)
• Hemostatic Techniques (standards)
• Hemostatics (chemistry, pharmacology, therapeutic use)
• Military Medicine (methods)
• Platelet Count
• Survival Rate
• Swine
• Thrombin (therapeutic use)
• Time Factors
• Wounds, Penetrating (complications)