Effect of supplementary feeding of vitamin K1 on difethialone treated Indian gerbil, Tatera indica Hardwicke in laboratory.

Abstract

Two dosages (1 and 2 mg/kg) of vitamin K1 supplementation for 5 and 15 days were given to Indian gerbil T. indica fed on difethialone bait (0.0025%) for one day. The results indicated that the lower dosage could not reverse the anticoagulation process, however the period of mortality was considerably increased from 3-9 days (in control) to 5-14 days (5 days supplementation regime). Subsequently when the vitamin K1 dosage was doubled and given for 15 days, there was 100% reversal of anticoagulation process and all the test gerbils became normal within a month of poisoning with difethialone bait.

• Authors: Vipin Chaudhary, R S Tripathi, F S Poonia
• Journal: Indian journal of experimental biology (Indian J Exp Biol) Vol. 42 Issue 3 Pg. 297-302 (Mar 2004) ISSN: 0019-5189 [Print] India
• PMID: 15233301 (Publication Type: Journal Article)

Chemical References

• 4-Hydroxycoumarins
• Anticoagulants
• Rodenticides
• Vitamin K 1
• difethialone

Topics

• 4-Hydroxycoumarins (poisoning)
• Animal Feed
• Animals
• Anticoagulants (pharmacology)
• Dietary Supplements
• Gerbillinae
• Rodenticides (poisoning)
• Time Factors
• Vitamin K 1 (pharmacology)