Hypercholesterolaemia in a family of rough collie dogs.

Abstract

A family of five privately owned rough collie dogs was referred for corneal lipidosis and also suffered from hypercholesterolaemia. The hypercholesterolaemia was characterised by an increase in the alpha-2 high density lipoprotein-1 band and was due to an increase in the cholesterol content of the very low density lipoprotein, low density lipoprotein and possibly the high density lipoprotein-1 fractions. A low-fat and energy-restricted diet did not reduce either total cholesterol or the corneal lipidosis. Corneal lipidosis regressed with short-chain fructo-oligosaccharide supplementation. However, the effects of short-chain fructo-oligosaccharides on total cholesterol were transient and variable.

• Authors: I Jeusette, M Grauwels, C Cuvelier, C Tonglet, L Istasse, M Diez
• Journal: The Journal of small animal practice (J Small Anim Pract) Vol. 45 Issue 6 Pg. 319-24 (Jun 2004) ISSN: 0022-4510 [Print] England
• PMID: 15206480 (Publication Type: Case Reports, Journal Article)

Chemical References

• Cholesterol, HDL
• Cholesterol, LDL
• Cholesterol, VLDL
• Cholesterol

Topics

• Animals
• Cholesterol (blood)
• Cholesterol, HDL (blood)
• Cholesterol, LDL (blood)
• Cholesterol, VLDL (blood)
• Diagnosis, Differential
• Dog Diseases (blood, diagnosis, genetics)
• Dogs
• Female
• Genetic Predisposition to Disease
• Hypercholesterolemia (diagnosis, genetics, veterinary)
• Male
• Pedigree