Comparison of intra-arterial versus intravenous 5-fluorouracil administration on epidermal squamous cell carcinoma in sheep.

Abstract

Clinical evidence that intra-arterial chemotherapy is more effective in regressing head and neck cancers than equivalent intravenous doses is lacking. Intra-arterial versus intravenous 5-fluorouracil infusion was compared in a naturally occurring, auricular epidermal squamous cell cancer in sheep. Of 18 lesions infused intra-arterially and of 18 infused intravenously with the same dose, 39 and 11%, respectively responded objectively (over 50% regression); mean (S.E.) tumour volume reduction was 37(23) and 18(22)%, respectively. There was a statistically significant difference in the mean tumour response and in numbers of tumours regressing by at least 40% of tumour volume (50% of intra-arterial treated tumours compared with 11% of intravenous treated lesions) after the 16 day total infusion time in favour of intra-arterial treatment. Technically, the intra-arterial route in this model was an improvement on previous small animal models. These findings lend support to the need for continuing clinical study of intra-arterial infusion.

• Authors: G J Harker, F O Stephens
• Journal: European journal of cancer (Oxford, England : 1990) (Eur J Cancer) Vol. 28A Issue 8-9 Pg. 1437-41 ( 1992) ISSN: 0959-8049 [Print] England
• PMID: 1515266 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Fluorouracil

Topics

• Animals
• Carcinoma, Squamous Cell (drug therapy)
• Disease Models, Animal
• Drug Administration Schedule
• Ear Neoplasms (drug therapy)
• Fluorouracil (administration & dosage, therapeutic use)
• Infusions, Intra-Arterial
• Infusions, Intravenous
• Sheep
• Skin Neoplasms (drug therapy)