Activation of porcine cytomegalovirus, but not porcine lymphotropic herpesvirus, in pig-to-baboon xenotransplantation.
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| Abstract |
Tissue-invasive disease due to porcine cytomegalovirus (PCMV) has been demonstrated after pig-to-baboon solid-organ xenotransplantation. Porcine lymphotropic herpesvirus (PLHV)-1 is associated with B cell proliferation and posttransplant lymphoproliferative disorder after allogeneic bone marrow transplantation in swine but has not been observed in pig-to-primate xenotransplantation. Activation of PCMV and PLHV-1 was investigated in 22 pig-to-baboon xenotransplants by use of quantitative polymerase chain reaction. PCMV was found in all xenografts; increased viral replication occurred in 68% of xenografts during immunosuppression. PLHV-1 was found in 12 xenografts (55%); no increases in viral replication occurred during immunosuppression. Control immunosuppressed swine coinfected with PCMV and PLHV-1 had activation of PCMV but not PLHV-1. PCMV, but not PLHV-1, is activated in solid-organ xenotransplantation.
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| Authors | Nicolas J Mueller, Christine Livingston, Christoph Knosalla, Rolf N Barth, Shin Yamamoto, Bernd Gollackner, Frank J M F Dor, Leo Buhler, David H Sachs, Kazuhiko Yamada, David K C Cooper, Jay A Fishman |
| Journal | The Journal of infectious diseases (J Infect Dis) Vol. 189 Issue 9 Pg. 1628-33 (May 01 2004) ISSN: 0022-1899 [Print] United States |
| PMID | 15116299 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.) |
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