Human platelet antigen systems in allogeneic peripheral blood progenitor cell transplantation: effect of human platelet antigen mismatch on platelet engraftment and graft-versus-host disease.

Abstract

BACKGROUND:

Alloimmune incompatibility in allo-geneic stem cell transplantation (ASCT), pregnancy, and blood transfusion might trigger an immune response with clinical consequences. Human PLT antigens (HPAs), which play a significant role in pregnancy or blood transfusion-associated alloimmune thrombocytopenia, are also expressed on the surface of tissues affected by GVHD. Thus, HPA mismatch in HLA-identical ASCT could play a potential role in PLT engraftment and GVHD.

STUDY DESIGN AND METHODS:

We studied the HPA-1, -2, and -5 genotypes in Caucasian donors and patients involved in 77 HLA-identical ASCTs. We evaluated the association of HPA compatibility with clinical outcome, analyzing the relevance of host-versus-donor HPA incompatibility in PLT engraftment and donor-versus-host HPA incompatibility in GVHD.

RESULTS:

PLT engraftment and transfusion require-ments were similar in HPA-compatible and HPA-incompatible ASCT. Cases with severe thrombocytopenia or significant delayed PLT engraftment did not display host-versus-donor HPA incompatibility. Moreover, the incidence of GVHD did not correlate with HPA compatibility.

CONCLUSION:

Our results support no role for these antigens in immune complications of ASCT: PLT engraftment, requirement of PLT transfusions, and GVHD.

• Authors: M D García-Malo, J Corral, M González, C Solano, R González-Conejero, M D Caballero, R Pérez, J M Moraleda, V Vicente
• Journal: Transfusion (Transfusion) Vol. 44 Issue 5 Pg. 771-6 (May 2004) ISSN: 0041-1132 [Print] United States
• PMID: 15104661 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antigens, Human Platelet

Topics

• Adolescent
• Adult
• Aged
• Antigens, Human Platelet (analysis, immunology)
• Female
• Graft vs Host Disease (etiology)
• Humans
• Male
• Middle Aged
• Peripheral Blood Stem Cell Transplantation (adverse effects)
• Platelet Transfusion
• Transplantation, Homologous