NIN, a gene encoding a CEP110-like centrosomal protein, is fused to PDGFRB in a patient with a t(5;14)(q33;q24) and an imatinib-responsive myeloproliferative disorder.

Abstract	We describe a new PDGFRB fusion associated with a t(5;14)(q33;q24) in a patient with a longstanding chronic myeloproliferative disorder with eosinophilia. After confirmation of PDGFRB involvement and definition of the chromosome 14 breakpoint by fluorescence in situ hybridization, candidate partner genes were selected on the basis of the presence of predicted oligomerization domains believed to be an essential feature of tyrosine kinase fusion proteins. We demonstrate that the t(5;14) fuses PDGFRB to NIN, a gene encoding a centrosomal protein with CEP110-like function. After treatment with imatinib, the patient achieved hematological and cytogenetical remission, but NIN-PDGFRB mRNA remained detectable by reverse transcription-PCR.
Authors	José L Vizmanos, Francisco J Novo, José P Román, E Joanna Baxter, Idoya Lahortiga, María J Larráyoz, María D Odero, Pilar Giraldo, María J Calasanz, Nicholas C P Cross
Journal	Cancer research (Cancer Res) Vol. 64 Issue 8 Pg. 2673-6 (Apr 15 2004) ISSN: 0008-5472 [Print] United States
PMID	15087377 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antineoplastic Agents Benzamides Oncogene Proteins, Fusion Piperazines Pyrimidines Imatinib Mesylate Receptor Protein-Tyrosine Kinases Receptor, Fibroblast Growth Factor, Type 1 Receptor, Platelet-Derived Growth Factor beta CEP110-FGFR1 fusion protein, human
Topics	Adult Antineoplastic Agents (therapeutic use) Base Sequence Benzamides Chromosomes, Human, Pair 14 (genetics) Chromosomes, Human, Pair 5 (genetics) Gene Rearrangement Humans Imatinib Mesylate In Situ Hybridization, Fluorescence Male Molecular Sequence Data Myeloproliferative Disorders (drug therapy, genetics) Oncogene Proteins, Fusion (genetics) Piperazines (therapeutic use) Pyrimidines (therapeutic use) Receptor Protein-Tyrosine Kinases (genetics) Receptor, Fibroblast Growth Factor, Type 1 Receptor, Platelet-Derived Growth Factor beta (genetics) Reverse Transcriptase Polymerase Chain Reaction Translocation, Genetic

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