[Complicating neonatal Escherichia coli meningitis].

Abstract

Neonatal Escherichia coli meningitis is a serious disease with high mortality and poor outcome. Ventriculitis, brain abscess and subdural empyema are frequent, with no homogeneous recommendations available for these complications. The case of a newborn infant who developed sepsis and meningitis caused by E. coli is presented. During intravenous treatment with ampicillin, cefotaxime and gentamycin in recommended doses, the patient developed severe subdural abscesses detected on MRI. After consequent antibiotic therapy over 2 months with fosfomycin, amikacin and meropenem the patient improved clinically and the abscesses regressed and disappeared without neurosurgical intervention. At the age of 6.5 months the infant is healthy and well developed. The conservative treatment of subdural abscesses complicating neonatal Escherichia coli meningitis without neurosurgical intervention is possible. The treatment of the individual case should be discussed between pediatrician and neurosurgeon.

• Authors: J Sonntag, D Kaczmarek, G Brinkmann, G Kammler, H H Hellwege
• Journal: Zeitschrift fur Geburtshilfe und Neonatologie (Z Geburtshilfe Neonatol) Vol. 208 Issue 1 Pg. 32-5 (Feb 2004) ISSN: 0948-2393 [Print] Germany
• Vernacular Title: Subdurale gekammerte Abszesse nach neonataler Colimeningitis - Fallbericht über eine erfolgreiche konservative Therapie -
• PMID: 15039890 (Publication Type: Case Reports, Journal Article)

Chemical References

• Thienamycins
• Fosfomycin
• Amikacin
• Meropenem

Topics

• Amikacin (administration & dosage)
• Brain (pathology)
• Drug Therapy, Combination (therapeutic use)
• Echoencephalography
• Empyema, Subdural (diagnosis, drug therapy)
• Escherichia coli Infections (diagnosis, drug therapy)
• Female
• Fosfomycin (administration & dosage)
• Humans
• Infant, Newborn
• Intensive Care, Neonatal
• Magnetic Resonance Imaging
• Meningitis, Escherichia coli (diagnosis, drug therapy)
• Meropenem
• Microbial Sensitivity Tests
• Patient Care Team
• Thienamycins (administration & dosage)
• Treatment Outcome