[Successful anesthetic management of patients with poor ventricular function using the phosphodiesterase III inhibitor, olprinone, during major cardiovascular procedures].
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| Abstract |
We administered olprinone, a newly developed phosphodiesterase III inhibitor, commencing before induction of general anesthesia to patients with poor ventricular function during major cardiovascular procedures. Case 1 patient underwent off-pump CABG for acute myocardial infarction. Although he was in a shock state, olprinone improved the contractility of viable myocardium, increased the cardiac index, and decreased the pulmonary artery pressure. Case 2 patient underwent off-pump CABG for unstable angina. Olprinone significantly increased the cardiac index and the mixed venous oxygen saturation. Case 3 patient underwent graft replacement for rupture of a dissected descending aorta. Although he showed ischemic cardiomyopathy with diffuse hypokinetic left ventricle, olprinone drastically improved the contractility of the heart. Olprinone was very effective for improving ventricular dysfunction; its institution prior to induction of anesthesia made successful anesthetic management possible without resorting to a mechanical assist device like the intra-aortic balloon pump.
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| Authors | Kyung-ho Chang, Makoto Ogawa, Masahiko Bougaki, Takayuki Sugano, Kazuo Hanaoka |
| Journal | Masui. The Japanese journal of anesthesiology (Masui) Vol. 53 Issue 2 Pg. 143-9 (Feb 2004) ISSN: 0021-4892 [Print] Japan |
| PMID | 15011421 (Publication Type: Case Reports, English Abstract, Journal Article) |
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