Improving cardiopulmonary bypass: heparin-coated circuits.

Abstract

Heparin-coated circuits have been repeatedly proven to reduce the inflammatory response and foreign surface activation triggered upon initiation of cardiopulmonary bypass (CPB). In recent years, increasing numbers of studies are proving significant reductions in postoperative blood loss and transfusion requirements and improvements in clinical outcomes as a result of heparin-coated circuits. These results are promising steps in our efforts to improve CPB, as our patient population gets older and more complicated.

• Authors: Craig Vocelka, Gina Lindley
• Journal: The journal of extra-corporeal technology (J Extra Corpor Technol) Vol. 35 Issue 4 Pg. 312-6 (Dec 2003) ISSN: 0022-1058 [Print] United States
• PMID: 14979422 (Publication Type: Journal Article, Review)

Chemical References

• Anticoagulants
• Blood Coagulation Factors
• Coated Materials, Biocompatible
• Heparin

Topics

• Anticoagulants (administration & dosage, pharmacology)
• Blood Coagulation (drug effects)
• Blood Coagulation Factors (drug effects)
• Cardiopulmonary Bypass (adverse effects, instrumentation, methods)
• Coated Materials, Biocompatible
• Drug Delivery Systems
• Heparin (administration & dosage, pharmacology)
• Humans
• Inflammation (prevention & control)
• Postoperative Hemorrhage (prevention & control)
• Risk Factors