Abstract |
The differentiating properties of retinoic acid (RA) have been used beneficially for the treatment of Acute Promyelocytic Leukemia (APL) for more than a decade. However, the molecular mechanisms of how RA induces APL cell differentiation are still poorly understood. In our previous work, we provided a novel mechanism to explain the unique sensitivity to RA of APL cells. We proposed that C/EBPbeta is an ATRA-dependent PML/RARA target gene and that its activation is critical during ATRA-induced differentiation of APL cells. Here, I discuss how C/EBPbeta could be an important gene in APL pathogenesis.
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Authors | Estelle Duprez |
Journal | Cell cycle (Georgetown, Tex.)
(Cell Cycle)
Vol. 3
Issue 4
Pg. 389-90
(Apr 2004)
ISSN: 1538-4101 [Print] United States |
PMID | 14976428
(Publication Type: Journal Article)
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Chemical References |
- CCAAT-Enhancer-Binding Protein-beta
- RNA, Messenger
- Tretinoin
- Cyclic AMP
|
Topics |
- CCAAT-Enhancer-Binding Protein-beta
(physiology)
- Cell Cycle
- Cell Differentiation
- Cyclic AMP
(metabolism)
- Enzyme Activation
- Humans
- Leukemia, Promyelocytic, Acute
(metabolism)
- Neoplasms
(genetics)
- Oligonucleotide Array Sequence Analysis
- RNA, Messenger
(metabolism)
- Signal Transduction
- Transcriptional Activation
- Tretinoin
(metabolism)
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