Abstract | OBJECTIVE: DESIGN: Prospective open label drug efficacy study. SETTING: Health centre in large peri-urban township adjacent to Blantyre, Malawi. PARTICIPANTS: MAIN OUTCOME MEASURES: Therapeutic efficacy and parasitological resistance to standard sulfadoxine-pyrimethamine treatment at 14 days and 28 days of follow up. RESULTS: Therapeutic efficacy remained stable, with adequate clinical response rates of 80% or higher throughout the five years of the study. Analysis of follow up to 28 days showed modest but significant trends towards diminishing clinical and parasitological efficacy over time within the study period. CONCLUSION:
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Authors | Christopher V Plowe, James G Kublin, Fraction K Dzinjalamala, Deborah S Kamwendo, Rabia A G Mukadam, Phillips Chimpeni, Malcolm E Molyneux, Terrie E Taylor |
Journal | BMJ (Clinical research ed.)
(BMJ)
Vol. 328
Issue 7439
Pg. 545
(Mar 06 2004)
ISSN: 1756-1833 [Electronic] England |
PMID | 14757706
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Antimalarials
- Drug Combinations
- fanasil, pyrimethamine drug combination
- Sulfadoxine
- Pyrimethamine
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Topics |
- Adolescent
- Adult
- Aged
- Anemia
(etiology)
- Antimalarials
(therapeutic use)
- Child
- Child, Preschool
- Drug Combinations
- Drug Evaluation
- Drug Resistance
- Follow-Up Studies
- Humans
- Infant
- Malaria, Falciparum
(drug therapy)
- Malawi
- Middle Aged
- Prospective Studies
- Pyrimethamine
(therapeutic use)
- Sulfadoxine
(therapeutic use)
- Treatment Outcome
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