Structure, activation, and biology of calpain.

Abstract

Variation in the calpain 10 gene has recently been shown to be associated with type 2 diabetes by positional cloning. Since then, studies on calpain 10 have been started in correlation with diabetes and insulin-mediated signaling. In this review, the activation mechanism of calpain by calcium ions, which is essential to understand its physiological functions, is discussed on the basis of recent X-ray structural analyses. Further, special features of the structure of calpain 10 that differ from those of typical micro - or m-calpain used in most studies are summarized together with discussion of the physiological function of calpain with respect to type 2 diabetes.

• Authors: Koichi Suzuki, Shoji Hata, Yukiko Kawabata, Hiroyuki Sorimachi
• Journal: Diabetes (Diabetes) Vol. 53 Suppl 1 Pg. S12-8 (Feb 2004) ISSN: 0012-1797 [Print] United States
• PMID: 14749260 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Calpain
• calpain 10
• Calcium

Topics

• Calcium
• Calpain (chemistry, genetics, physiology)
• Cloning, Molecular
• Diabetes Mellitus, Type 2 (genetics)
• Humans
• Models, Molecular
• Protein Conformation