Orofacial granulomas after injection of cosmetic fillers. Histopathologic and clinical study of 11 cases.

Abstract

BACKGROUND:

Purposely, cosmetic injections in orofacial tissues of various resorbable, biodegradable, or permanent fillers may be followed by development of foreign-body granulomas. The aim of this article is to contribute to the histologic identification of the filler material.

METHODS:

Histologic and clinical features of 11 cases of granulomas on orofacial fillers are described.

RESULTS:

Only 3/11 patients knew the nature of the injected product. Four histologic patterns were found: (i) Artecoll, (ii) Dermalive, and (iii) New-Fill granuloma, all three of the classic giant cell granuloma type, differing in respect of foreign particles; and (iv) Liquid Silicone granuloma, which featured a cystic and macrophagic type. Information was often missing or misleading, patients or practitioners being reluctant to give the details.

CONCLUSION:

Increasing demand for orofacial tissue augmentation makes pathologists face new, and sometimes, puzzling granuloma types. Identification of the foreign product might be required for therapeutic or medico-legal reasons.

• Authors: T Lombardi, J Samson, F Plantier, C Husson, R Küffer
• Journal: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (J Oral Pathol Med) Vol. 33 Issue 2 Pg. 115-20 (Feb 2004) ISSN: 0904-2512 [Print] Denmark
• PMID: 14720198 (Publication Type: Case Reports, Journal Article)

Chemical References

• Acrylates
• Artecoll
• Dermalive
• Hydrogels
• New-Fill
• Polymers
• Silicones
• Hydrogel, Polyethylene Glycol Dimethacrylate
• Lactic Acid
• Mannitol
• Cellulose
• Hyaluronic Acid
• Collagen
• Polymethyl Methacrylate

Topics

• Acrylates (adverse effects)
• Adult
• Aged
• Aged, 80 and over
• Cellulose (adverse effects)
• Collagen (adverse effects)
• Cosmetic Techniques (adverse effects)
• Face (pathology)
• Female
• Granuloma, Foreign-Body (chemically induced, pathology)
• Granuloma, Giant Cell (chemically induced, pathology)
• Humans
• Hyaluronic Acid (adverse effects)
• Hydrogel, Polyethylene Glycol Dimethacrylate (adverse effects)
• Hydrogels (adverse effects)
• Injections
• Lactic Acid (adverse effects)
• Lip Diseases (chemically induced)
• Mannitol (adverse effects)
• Middle Aged
• Polymers (adverse effects)
• Polymethyl Methacrylate (adverse effects, analogs & derivatives)
• Prostheses and Implants (adverse effects)
• Silicones (adverse effects)