[Study of the antihypoxic effect of eburnamonine in acute and recurrent anoxia on the cerebral electric activity in curarized rats. Comparison with vincamine].

Abstract

Using venous infusion (0.25 mg/kg min.), l-eburnamonine decreases the electroencephalographic modifications induced by acute asphyxic anoxia in curarized rats. This activity appears when the total dose administrated before the first asphyxia is approximatively 5 mg/kg. In such conditions, its protective activity is precocious and long lasting. In the same experimental conditions, vincamine assumes a protective activity only during a short time. The results are discussed in terms of selectivity of the method used and in terms of cerebral antihypoxic properties of l-eburnamonine.

• Authors: J Van Den Driessche, P Linée, P Lacroix, J B Le Pollès
• Journal: Comptes rendus des seances de la Societe de biologie et de ses filiales (C R Seances Soc Biol Fil) Vol. 171 Issue 5 Pg. 1081-7 ( 1977) ISSN: 0037-9026 [Print] France
• Vernacular Title: Etude de la protection exercée par la l-éburnamonine vis-à-vis de l'anoxie asphyxique alguë et itérative sur l'activité électrique cérébrale du rat curarisé. Comparaison avec la vincamine.
• PMID: 146550 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Vinca Alkaloids

Topics

• Animals
• Brain (drug effects, physiopathology)
• Cerebrovascular Circulation (drug effects)
• Depression, Chemical
• Electroencephalography
• Hypoxia (physiopathology, prevention & control)
• Male
• Rats
• Vinca Alkaloids (pharmacology, therapeutic use)