Transpupillary thermotherapy for treatment of choroidal neovascularization secondary to age-related macular degeneration in Indian eyes.

Abstract

AIM:

To evaluate the efficacy of transpupillary thermotherapy (TTT) for treatment of subfoveal choroidal neovascularisation (CNV) secondary to age-related macular degeneration (AMD), and to define accurate power settings for this procedure in Indian eyes.

METHODS:

A prospective, nonrandomised study of 160 eyes of 144 patients with subfoveal CNV. The laser settings included 2 mm spot and 300 mw power or 3 mm spot and 400-600 mw power. Two separate 3 mm spots were used in larger lesions. The treatment was given for 60 seconds at each point.

RESULTS:

Ninety-nine eyes had classic membranes and 61 eyes had occult membranes. Following treatment, 79 of 99 (79.8%) classic and 52 of 61 (85%) occult membranes regressed. Visual improvement (> or = 2 lines) was seen in 29 (29.3%) eyes and 12 (19.6%) eyes; visual stabilisation (1 line) in 39 (39.4%) eyes, and 35 (57.4%) eyes; and reduction of vision (< or = 2 lines) in 31 (31.3%) eyes and 14 (22.9%) eyes with classic and occult membranes respectively. Mean follow-up was 12 months. One patient suffered inadvertant foveal burn.

CONCLUSION:

TTT is effective in the management of subfoveal membranes in Indian eyes. They respond to lower energy levels compared to the Caucasian eyes.

• Authors: Manish Nagpal, Kamal Nagpal, Shobhana Sharma, Jyoti Puri, Pran N Nagpal
• Journal: Indian journal of ophthalmology (Indian J Ophthalmol) Vol. 51 Issue 3 Pg. 243-50 (Sep 2003) ISSN: 0301-4738 [Print] India
• PMID: 14601850 (Publication Type: Clinical Trial, Comparative Study, Journal Article)

Topics

• Choroidal Neovascularization (etiology, therapy)
• Female
• Fluorescein Angiography
• Humans
• Hyperthermia, Induced (methods)
• Laser Therapy
• Macular Degeneration (complications, therapy)
• Male
• Prospective Studies
• Pupil
• Treatment Outcome
• Visual Acuity