[The efficacy of hepatoprotectors and cytochrome P-450 inducers in correcting the functional activity of the hepatocyte microsomal system in an acute lesion of the liver in prepuberty].

Abstract

Intragastric CCl4 inhibited the activity of and lowered the levels of the major components of the hepatic monoohygenase enzyme system in one-month rats. Benzonal was found to be more effective in correcting the impaired monooxygenase enzyme system of hepatic cells in immature rats with acute hepatitis than silibor, phytin and zyxorin.

• Authors: Z Z Khakimov, A Kh Rakhmanov
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 1992 Jul-Aug Vol. 55 Issue 4 Pg. 16-7 ISSN: 0869-2092 [Print] Russia (Federation)
• Vernacular Title: Izuchenie éffektivnosti gepatoprotektorov i induktorov tsitokhroma P-450 v korrektsii funktsional'noĭ aktivnosti mikrosomal'noĭ sistemy gepatotsitov pri ostrom porazhenii pecheni v prepubertatnom periode.
• PMID: 1458177 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Cytochrome P-450 Enzyme System
• Oxygenases

Topics

• Acute Disease
• Animals
• Carbon Tetrachloride Poisoning (complications, drug therapy, enzymology)
• Chemical and Drug Induced Liver Injury (drug therapy, enzymology, etiology)
• Cytochrome P-450 Enzyme System (biosynthesis, drug effects)
• Drug Evaluation, Preclinical
• Enzyme Induction (drug effects)
• Female
• Liver (drug effects)
• Male
• Microsomes, Liver (drug effects, enzymology)
• Oxygenases (drug effects, metabolism)
• Rats
• Sexual Maturation (drug effects)
• Time Factors