Abstract |
A 46-year-old female presented with POEMS syndrome. Hemodialysis was initiated to control severe anasarca and declining renal function. Corticosteroids were effective in treating renal insufficiency and other symptoms. Serum interleukin 6 (IL-6) was elevated before the corticosteroid therapy but returned to the normal level under the therapy. Immunostaining for the kidney tissue obtained by a renal biopsy showed a diffuse distribution of IL-6 in the glomeruli; thus, in contrast to normal, IL-6 was detected not only in mesangial cells but also in endothelial cells. IL-6 was also distributed in capillaries in the interstitium. While these results suggest a pathogenic role of IL-6 in POEMS syndrome, other factors may be necessary for the full expression of symptoms. Furthermore, it is suggested that chronically stimulated glomerular endothelial cells are capable of producing IL-6.
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Authors | A Fukatsu, Y Ito, Y Yuzawa, F Yoshida, M Kato, K Miyakawa, S Matsuo |
Journal | Nephron
(Nephron)
Vol. 62
Issue 1
Pg. 47-51
( 1992)
ISSN: 1660-8151 [Print] Switzerland |
PMID | 1436291
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Adrenal Cortex Hormones
- Interleukin-6
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Topics |
- Adrenal Cortex Hormones
(therapeutic use)
- Biopsy
- Female
- Fluorescent Antibody Technique
- Humans
- Interleukin-6
(analysis, blood, physiology)
- Kidney
(chemistry, pathology)
- Middle Aged
- POEMS Syndrome
(blood, drug therapy)
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