Studies of Org 10172 in patients with acute ischemic stroke. TOAST Study Group.

Abstract

This report presents data from pilot studies of Org 10172 in the management of patients with acute ischemic stroke. The studies have established a potentially optimal dosage and treatment regimen and have provided information for the development of a large randomized trial. The trial of Org 10172 in acute stroke treatment is now underway in the United States.

• Authors: H P Adams Jr, R F Woolson, J Biller, W Clarke
• Journal: Haemostasis (Haemostasis) Vol. 22 Issue 2 Pg. 99-103 ( 1992) ISSN: 0301-0147 [Print] Switzerland
• PMID: 1379970 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, U.S. Gov't, P.H.S., Review)

Chemical References

• Factor Xa Inhibitors
• Fibrinolytic Agents
• Glycosaminoglycans
• Heparinoids
• Dermatan Sulfate
• Prothrombin
• Factor IIa
• Chondroitin Sulfates
• Heparitin Sulfate
• danaparoid

Topics

• Brain Ischemia (drug therapy, epidemiology)
• Chondroitin Sulfates
• Dermatan Sulfate
• Drug Evaluation
• Factor Xa Inhibitors
• Fibrinolytic Agents (administration & dosage, adverse effects, therapeutic use)
• Glycosaminoglycans (administration & dosage, adverse effects, therapeutic use)
• Hemorrhage (chemically induced)
• Heparinoids (administration & dosage, adverse effects, therapeutic use)
• Heparitin Sulfate
• Humans
• Incidence
• Pilot Projects
• Prothrombin (antagonists & inhibitors)
• Thrombolytic Therapy
• Treatment Outcome
• United States (epidemiology)