[The effect of the S1A-receptor agonist ipsapirone on behavior types in wild and domesticated rats].

Abstract

Selective agonist of 1A subtype of serotonine receptors ipsapirone inhibited manifestation of affective kinds of aggression in wild and domesticated rats. Administration of ipsapirone (10 mg/kg) decreased the number of aggressive attacks of wild and domesticated rats in the test of shock-induced aggression and blocked manifestation of defensive reaction to the experimenter in wild rats. Neophobia in wild rats decreased under the influence of ipsapirone. At the same time ipsapirone did not change mouse-killing behaviour either in wild or in domesticated rats. Probably, 5-HT1A receptors the aggressive regulate reaction, which are parts of the complex of defensive behaviour of the wild animals.

• Authors: E M Nikulina
• Journal: Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova (Zh Vyssh Nerv Deiat Im I P Pavlova) 1991 Nov-Dec Vol. 41 Issue 6 Pg. 1149-53 ISSN: 0044-4677 [Print] Russia (Federation)
• Vernacular Title: Vliianie agonista S1A-retseptorov ipsapirona na nekotorye vidy povedeniia dikikh i domestitsirovannykh krys.
• PMID: 1369564 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Pyrimidines
• Receptors, Serotonin
• Serotonin Receptor Agonists
• ipsapirone

Topics

• Aggression (drug effects, physiology)
• Animals
• Animals, Domestic
• Animals, Wild
• Behavior, Animal (drug effects, physiology)
• Male
• Phobic Disorders (physiopathology)
• Pyrimidines (pharmacology)
• Rats
• Reaction Time (drug effects, physiology)
• Receptors, Serotonin (drug effects, physiology)
• Serotonin Receptor Agonists (pharmacology)
• Statistics, Nonparametric