Hyperthermia induced by m-trifluoromethylphenylpiperazine (TFMPP) or m-chlorophenylpiperazine (m-CPP) in heat-adapted rats.

Abstract

TFMPP and m-CPP, non-selective 5-HT agonists, administered in doses of 1-20 mg/kg evoked hyperthermia in rats at a high ambient temperature (28 degrees C). The hyperthermic effect of TFMPP (10 mg/kg) or m-CPP (10 mg/kg) was dose-dependently antagonized by the 5-HT1c and 5-HT2 receptor antagonists mesulergine (0.5-4 mg/kg), ketanserin (0.6-2.5 mg/kg) and ritanserin (0.5-2 mg/kg) and by the non-selective 5-HT antagonist metergoline (0.5-1 mg/kg), or was attenuated by the 5-HT1A, 5-HT2 and dopamine receptor antagonist spiperone (3 mg/kg, but not 0.3 or 1 mg/kg). On the other hand, the 5-HT1A, 5-HT1B and beta adrenoceptor antagonists pindolol (2 mg/kg) and cyanopindolol (2 mg/kg), the 5-HT1A receptor agonist/antagonist ipsapirone (10 and 35 mg/kg) and haloperidol (0.25 and 0.5 mg/kg) showed a tendency towards enhancing the TFMPP- or m-CPP-induced hyperthermia. The 5-HT1A and alpha 1-adrenoceptor antagonist NAN-190 (1-4 mg/kg), the 5-HT3 antagonists tropisetron (0.01-1 mg/kg) and zacopride (0.5 and 1 mg/kg), the beta-blockers betaxolol (8 mg/kg) and ICI 118, 551 (8 mg/kg), which have no affinity for 5-HT receptors and prazosin (1 mg/kg), did not affect the hyperthermic effect of TFMPP or m-CPP. The hyperthermias studied were not modified, in animals with 5-HT lesion produced by p-chloroamphetamine (PCA) either. All the drugs used as putative receptor antagonists, as well as PCA, did not change or decreased (ipsapirone) the body temperature in heat-adapted rats.(ABSTRACT TRUNCATED AT 250 WORDS)

• Authors: A Kłodzińska, E Chojnacka-Wójcik
• Journal: Psychopharmacology (Psychopharmacology (Berl)) Vol. 109 Issue 4 Pg. 466-72 ( 1992) ISSN: 0033-3158 [Print] Germany
• PMID: 1365864 (Publication Type: Journal Article)

Chemical References

• Adrenergic beta-Antagonists
• Dopamine Antagonists
• Piperazines
• Serotonin Antagonists
• Serotonin Receptor Agonists
• 1-(3-trifluoromethylphenyl)piperazine
• p-Chloroamphetamine
• 1-(3-chlorophenyl)piperazine

Topics

• Adaptation, Physiological (physiology)
• Adrenergic beta-Antagonists (pharmacology)
• Animals
• Body Temperature (drug effects, physiology)
• Dopamine Antagonists (pharmacology)
• Dose-Response Relationship, Drug
• Fever (chemically induced, physiopathology)
• Hot Temperature
• Male
• Piperazines
• Rats
• Rats, Wistar
• Serotonin Antagonists (pharmacology)
• Serotonin Receptor Agonists
• p-Chloroamphetamine (pharmacology)