Efficiency of anti-anemic drug
Ferrum Lack when using it alone or together with enterosorbent Uvesorb has been studied on the model of
iron deficiency anemia (IDA) in pregnant rats. It is stated that three-fold blood-letting in total volume of 6 ml carried out prior to pregnancy causes symptoms of IDA. Over a period of the whole pregnancy the concentration of
hemoglobin and the concentration of erythrocytes were lower than in intact pregnant rats. Tissue
hypoxia characterized by disturbance of terminal microcirculation, capillary tissue diffusion and
oxygen utilization was observed in pregnant rats with
anemia model. Dysfunctional shifts in the system lipid peroxidation (LPO)-
antioxidant protection (AOP) as noncompensated process of
free-radical oxidation of
lipids were revealed in parallel. A comparative estimation of results from treatment in groups of animals which were given and not given enterosorbent Uvesorb together with anti-anemic drug
Ferrum Lack permitted determining the presence of anti-anemic and antihypoxic effects in both groups, though the latter was more pronounced in animals which were given enterosorbent. Various results were revealed relative to changes in the LPO-AOP system. When using drug
Ferrum Lack alone, the content of products of LPO-
lipid hydroperoxides and malonic dialdehyde increased in blood, whereas in group of animals which were given enterosorbent the number of these products was observed to significantly decrease.