[Auer rods-positive neutrophils observed at diagnosis increased after remission induction in patient with acute promyelocytic leukemia].

Abstract

50-year-old male was admitted to our hospital because of gingival bleeding and fever in August 1987. The leukocyte count was 13,300/microliters with 80.5% leukemic promyelocytes and bone marrow was hypercellular with 86.4% leukemic promyelocytes. A small number of mature neutrophils containing Auer rods were seen in bone marrow. On a diagnosis of acute promyelocytic leukemia and treated with induction chemotherapy consisting of behenoyl-arabinofuranosyl cytosine (BHAC), daunorubicin, 6-mercaptopurine (6-MP) and prednisolone (PSL) was reformed. After cytoreduction, leukemic cells reappeared in the peripheral blood, concomitant with mature neutrophils having Auer rods. Vitamin D3 was not effective as a differentiation inducing agent. Complete remission was obtained in November 1987 by the reinduction chemotherapy consisting of BHAC, aclarubicin, 6-MP and PSL. In this case, neutrophils with Auer rods might have been derived from the leukemic clone and differentiation of leukemic promyelocytes by intensive chemotherapy.

• Authors: E Ashihara, K Ohkawa, H Gotoh, N Oku, T Inaba, S Murakami, K Itoh, N Fujita, C Shimazaki, A Nishio
• Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) Vol. 33 Issue 5 Pg. 666-70 (May 1992) ISSN: 0485-1439 [Print] Japan
• PMID: 1321302 (Publication Type: Case Reports, Journal Article)

Chemical References

• Cytarabine
• Prednisolone
• enocitabine
• Mercaptopurine
• Daunorubicin

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Cell Differentiation (drug effects)
• Cytarabine (administration & dosage, analogs & derivatives)
• Daunorubicin (administration & dosage)
• Humans
• Inclusion Bodies (drug effects, pathology)
• Leukemia, Promyelocytic, Acute (drug therapy, pathology)
• Male
• Mercaptopurine (administration & dosage)
• Middle Aged
• Neutrophils (drug effects, pathology)
• Prednisolone (administration & dosage)
• Remission Induction