Abstract | PURPOSE OF REVIEW: RELEVANT FINDINGS: HIV-positive women have a higher prevalence of cervical HPV infection than HIV-negative women, and HPV infection is more persistent in the HIV-positive population. The incidence of high-grade CIN is increased in HIV-positive women. HAART has not been shown to affect HPV detection, and data on its effect on the natural history of CIN are mixed. Some studies show no effect of HAART on the natural history of CIN, and others show a statistically significant but modest beneficial effect. SUMMARY: Cervical HPV infection and CIN are clearly increased in HIV-positive women when compared with risk-matched HIV-negative women. HAART appears to have limited ability to clear HPV infection and induce regression of CIN in HIV-positive women. Combined with the high prevalence of cervical HPV infection and CIN, current data suggest that CIN should be aggressively sought and treated in HIV-positive women, including those who have responded well to HAART with good HIV viral load suppression and increasing CD4+ levels.
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Authors | Joel M Palefsky |
Journal | Current opinion in oncology
(Curr Opin Oncol)
Vol. 15
Issue 5
Pg. 382-8
(Sep 2003)
ISSN: 1040-8746 [Print] United States |
PMID | 12960521
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S., Review)
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Topics |
- Antiretroviral Therapy, Highly Active
- Female
- HIV Infections
(complications)
- Humans
- Papillomavirus Infections
(complications)
- Prevalence
- Risk Factors
- Uterine Cervical Neoplasms
(epidemiology, virology)
- Uterine Cervical Dysplasia
(epidemiology, virology)
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