Beta-secretase (BACE) and GSK-3 mRNA levels in Alzheimer's disease.

Abstract

Beta-secretase (BACE) and glycogen synthase kinase (GSK 3) are two enzymes thought to play a role in Alzheimer's disease. We extracted mRNA from 90 Alzheimer and 81 control brains. Levels of mRNA were quantified for BACE and GSK 3 with TaqMan real-time RT-PCR. We found no change in the Alzheimer's disease brains relative to controls for either the BACE or the GSK 3alpha mRNA levels.

• Authors: Paul Preece, David J Virley, Moheb Costandi, Robert Coombes, Stephen J Moss, Anne W Mudge, Elena Jazin, Nigel J Cairns
• Journal: Brain research. Molecular brain research (Brain Res Mol Brain Res) Vol. 116 Issue 1-2 Pg. 155-8 (Aug 19 2003) ISSN: 0169-328X [Print] Netherlands
• PMID: 12941471 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Amyloid beta-Protein Precursor
• Glial Fibrillary Acidic Protein
• Microtubule-Associated Proteins
• RNA, Messenger
• Glycogen Synthase Kinase 3
• Amyloid Precursor Protein Secretases
• Endopeptidases
• Aspartic Acid Endopeptidases
• BACE1 protein, human
• Phosphopyruvate Hydratase

Topics

• Alzheimer Disease (enzymology, genetics, metabolism)
• Amyloid Precursor Protein Secretases
• Amyloid beta-Protein Precursor (analysis, genetics)
• Aspartic Acid Endopeptidases
• Endopeptidases (genetics, metabolism)
• Female
• Glial Fibrillary Acidic Protein (analysis, genetics)
• Glycogen Synthase Kinase 3 (genetics, metabolism)
• Humans
• Male
• Microtubule-Associated Proteins (analysis, genetics)
• Phosphopyruvate Hydratase (analysis, genetics)
• RNA, Messenger (analysis, biosynthesis)
• Reverse Transcriptase Polymerase Chain Reaction (methods)
• Sex Characteristics