Serum amyloid A: a novel serum marker for the detection of systemic inflammatory response in cystitis.

Abstract

PURPOSE:

We compared serum amyloid A (SAA) protein, C-reactive protein (CRP), interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha as inflammatory markers for pyelonephritis and cystitis.

MATERIALS AND METHODS:

SAA, CRP, IL-6 and TNF-alpha were determined in serum from 69 consecutive patients with acute pyelonephritis (37) and acute cystitis (32) on admission to an infectious disease clinic and on examination at a primary health care center, respectively. Healthy blood donors served as controls.

RESULTS:

SAA showed a systemic inflammatory response in cystitis in 90% of patients compared with 23%, 42% and 0% for CRP, IL-6 and TNF-alpha, respectively. SAA and CRP had equally high efficiencies (0.96 and 0.94, respectively) for discriminating between pyelonephritis and cystitis while efficiencies for IL-6 (0.85) and TNF-alpha (0.91) were lower.

CONCLUSIONS:

SAA is a sensitive systemic marker in cystitis but is still useful in detecting pyelonephritis.

• Authors: A Lannergard, G Friman, A Larsson
• Journal: The Journal of urology (J Urol) Vol. 170 Issue 3 Pg. 804-6 (Sep 2003) ISSN: 0022-5347 [Print] United States
• PMID: 12913703 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Interleukin-6
• Serum Amyloid A Protein
• Tumor Necrosis Factor-alpha
• C-Reactive Protein

Topics

• Adult
• Aged
• Aged, 80 and over
• Biomarkers (blood)
• C-Reactive Protein (analysis)
• Cystitis (diagnosis)
• Female
• Humans
• Inflammation (diagnosis)
• Interleukin-6 (blood)
• Male
• Middle Aged
• Pyelonephritis (diagnosis)
• Serum Amyloid A Protein (analysis)
• Tumor Necrosis Factor-alpha (analysis)