[Portal vein thrombosis associated with factor V Leiden mutation in a woman who underwent exchange transfusion at birth].

Abstract

We report the case of a 18-year-old woman with portal vein thrombosis and chronic hepatitis C virus. Portal vein thrombosis was diagnosed by chance on ultrasound examination during initial hepatitis C virus-positive patient screening. The patient interview revealed a history including exchange transfusion at birth, followed by necrotising ulcerocolitis and septicemia. The investigation of general factors favoring thrombosis showed acquired protein S deficiency and heterozygous factor V Leiden mutation. This case demonstrates the value of systematic investigations for general thrombophilic factors in cases of portal vein thrombosis even when a local cause is found.

• Authors: Juliette Tchuenbou, Yannick Bacq, Béatrice Fimbel, Etienne-Henry Metman
• Journal: Gastroenterologie clinique et biologique (Gastroenterol Clin Biol) Vol. 27 Issue 6-7 Pg. 645-7 (Jun 2003) ISSN: 0399-8320 [Print] France
• Vernacular Title: Thrombose de la veine porte associée au facteur V Leiden chez une femme ayant eu une exsanguino-transfusion en période néonatale.
• PMID: 12910230 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• factor V Leiden
• Factor V

Topics

• Adolescent
• Exchange Transfusion, Whole Blood
• Factor V
• Female
• Humans
• Infant, Newborn
• Point Mutation
• Portal Vein
• Thrombosis (etiology)