Abstract |
Cross-sectional studies have associated obesity and other components of the so-called metabolic syndrome with low-grade inflammation. The temporal and causal relations of this association have not been fully explored. This study explored whether elevated levels of inflammation-sensitive plasma proteins (ISPs) ( fibrinogen, orosomucoid, alpha1-antitrypsin, haptoglobin, and ceruloplasmin) are associated with future weight gain. Five ISPs were measured in 2,821 nondiabetic healthy men (38-50 years of age) who were reexamined after a mean follow-up of 6.1 years. Future weight gain was studied in relation to the number of elevated ISPs (i.e., in the top quartile). The proportion with a large weight gain (75th percentile >/= 3.8 kg) was 21.0, 25.9, 26.8, and 28.3%, respectively, among men with none, one, two, and three or more ISPs in the top quartile (P for trend 0.0005). This relation remained significant after adjustments for weight at baseline, follow-up time, height (at baseline and follow-up), physical inactivity (at baseline and follow-up), smoking (at baseline and follow-up), high alcohol consumption, and insulin resistance. The relations were largely similar for all individual ISPs. Elevated ISP levels predict a large weight gain in middle-aged men. This relation could contribute to the relation between inflammation, the metabolic syndrome, and cardiovascular disease.
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Authors | Gunnar Engström, Bo Hedblad, Lars Stavenow, Peter Lind, Lars Janzon, Folke Lindgärde |
Journal | Diabetes
(Diabetes)
Vol. 52
Issue 8
Pg. 2097-101
(Aug 2003)
ISSN: 0012-1797 [Print] United States |
PMID | 12882928
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Haptoglobins
- Orosomucoid
- alpha 1-Antitrypsin
- Fibrinogen
- Ceruloplasmin
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Topics |
- Adult
- Ceruloplasmin
(metabolism)
- Cohort Studies
- Cross-Sectional Studies
- Fibrinogen
(metabolism)
- Follow-Up Studies
- Haptoglobins
(metabolism)
- Humans
- Inflammation
(blood, diagnosis, epidemiology)
- Male
- Middle Aged
- Obesity
(blood, diagnosis, epidemiology)
- Orosomucoid
(metabolism)
- Predictive Value of Tests
- Risk Factors
- Weight Gain
(physiology)
- alpha 1-Antitrypsin
(metabolism)
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