Abstract | BACKGROUND: OBJECTIVE: METHODS: A total of 28 patients were instructed to apply 2.5 g of clobetasol propionate to the right side of the scalp every night under occlusion with a plastic film. Treatment was performed 6 days a week for 6 months. When regrowth of terminal hair occurred, treatment was extended over the entire scalp. All patients were followed up for another 6 months. RESULTS: Of the 28 patients included in the study, 8 were treated successfully (28.5%). Regrowth of terminal hair began on the treated side 6 to 14 weeks after the start of treatment. Of these 8 patients, 3 had a relapse and were not able to maintain hair regrowth. CONCLUSION: Our study shows that clobetasol propionate 0.05% under occlusion is effective in inducing hair regrowth in patients with AT or AT/ alopecia universalis. Occurrence of hair regrowth only on the treated half of the scalp clearly shows that efficacy of treatment is a result of a local and not systemic effect of the drug. Although only 17.8% of patients had long-term benefit by treatment, our results were obtained in a population of patients with severe and refractory forms of the disease.
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Authors | Antonella Tosti, Bianca Maria Piraccini, Massimiliano Pazzaglia, Colombina Vincenzi |
Journal | Journal of the American Academy of Dermatology
(J Am Acad Dermatol)
Vol. 49
Issue 1
Pg. 96-8
(Jul 2003)
ISSN: 0190-9622 [Print] United States |
PMID | 12833016
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Anti-Inflammatory Agents
- Glucocorticoids
- Ointments
- Clobetasol
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Topics |
- Administration, Topical
- Adolescent
- Adult
- Alopecia Areata
(drug therapy)
- Anti-Inflammatory Agents
(therapeutic use)
- Clobetasol
(administration & dosage, analogs & derivatives, therapeutic use)
- Female
- Glucocorticoids
- Humans
- Male
- Ointments
- Treatment Outcome
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