Abstract | BACKGROUND: Studies on kidney transplantation have thus far mainly dealt with surgical techniques, immunology, and transplant tolerance. Disturbed mineral metabolism after renal denervation has not received much attention. Basic physiological research in short-term experiments has shown that experimental renal denervation in rats leads to parathormone (PTH)-independent hyperphosphaturia (HPU). HPU and other metabolic complications also have been described after clinical kidney transplantation. Furthermore, there is an unexpected increase in the risk of bone fracture. However, these studies have examined an organism pre-damaged with regard to the parathyroid and immunosuppression. Experimental investigations in syngeneic rats were performed to see whether HPU also occurs after transplantation and thus after denervation and which target organs are involved. METHODS: RESULTS: CONCLUSIONS:
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Authors | B Straub, M Müller, R Heicappell, M Schrader, C Goessl, K Miller |
Journal | Transplantation proceedings
(Transplant Proc)
Vol. 35
Issue 4
Pg. 1575-80
(Jun 2003)
ISSN: 0041-1345 [Print] United States |
PMID | 12826224
(Publication Type: Journal Article)
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Chemical References |
- Insulin
- Organ Preservation Solutions
- Phosphates
- University of Wisconsin-lactobionate solution
- Allopurinol
- Glutathione
- Adenosine
- Raffinose
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Topics |
- Adenosine
- Allopurinol
- Animals
- Bone and Bones
(metabolism)
- Calcinosis
(etiology)
- Disease Models, Animal
- Glutathione
- Insulin
- Kidney Diseases
(etiology)
- Kidney Transplantation
(adverse effects, physiology)
- Male
- Nephrectomy
- Organ Preservation
- Organ Preservation Solutions
- Phosphates
(urine)
- Raffinose
- Rats
- Rats, Inbred Lew
- Tissue and Organ Harvesting
- Transplantation, Isogeneic
- Urinalysis
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