Abstract | AIM: To observe the acute effect of the organophosphorous insecticide malathion on testicular function in mice. METHODS: RESULTS: The sperm count was decreased significantly 24 h after treatment and teratozoospermia was increased at day 35 and 40. The height of the seminiferous epithelium and the diameter of tubular lumen were decreased at day 8. The percentage of tubular blockade was increased between day 8 and 35. A decrease in testosterone plasma level was observed at day 16 after treatment. CONCLUSION:
Malathion damages male reproduction. The depletion of seminiferous tubules and the increase in teratozoospermia may be a genotoxic damage to the renewing spermatogonia, but the possibility of spermatogenic/spermiogenic disfunction due to a decrease in the plasma testosterone level can not be ruled out.
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Authors | Eduardo Bustos-Obregón, Patricio González-Hormazabal |
Journal | Asian journal of andrology
(Asian J Androl)
Vol. 5
Issue 2
Pg. 105-7
(Jun 2003)
ISSN: 1008-682X [Print] China |
PMID | 12778319
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Insecticides
- Testosterone
- Malathion
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Topics |
- Animals
- Insecticides
(pharmacology)
- Malathion
(pharmacology)
- Male
- Mice
- Mice, Inbred Strains
- Seminiferous Tubules
(drug effects, pathology)
- Sperm Count
- Spermatogenesis
(drug effects)
- Spermatozoa
(abnormalities)
- Testosterone
(antagonists & inhibitors, blood)
- Time Factors
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