Involvement of capsaicin-sensitive sensory nerves in cardioprotection of rutaecarpine in rats.
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| Abstract |
In the present study, we examined whether rutaecarpine protects against myocardial ischemia-reperfusion injury in rats and whether the protective effects of rutaecarpine are related to activation of capsaicin-sensitive sensory nerves. Rats were pretreated with rutaecarpine 10 min before the experiment, and then the left main coronary artery of rat hearts was subjected to 60-min occlusion followed by 3-h reperfusion. The infarct size, serum concentration of creatine kinase, and CGRP concentration in plasma were measured. Pretreatment with rutaecarpine (100 or 300 microg/kg, i.v.) significantly reduced infarct size and creatine kinase release concomitantly with a significant increase in plasma concentrations of CGRP. These effects of rutaecarpine were completely abolished by capsazepine (38 mg/kg, s.c.), a competitive vanilloid receptor antagonist, or by pretreatment with capsaicin (50 mg/kg, s.c.), which selectively depletes transmitters in capsaicin-sensitive sensory nerves. These results suggest that rutaecarpine protects against myocardial ischemia-reperfusion injury in rats and that the protective effects of rutaecarpine are related to activation of capsaicin-sensitive sensory nerves via activating vanilloid receptors.
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| Authors | Chang-Ping Hu, Nian-Sheng Li, Liang Xiao, Han-Wu Deng, Yuan-Jian Li |
| Journal | Regulatory peptides (Regul Pept) Vol. 114 Issue 1 Pg. 45-9 (Jun 15 2003) ISSN: 0167-0115 [Print] Netherlands |
| PMID | 12763639 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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